guanylate cyclase meaning in English
鸟苷酸环化酶
Examples
- Harrison p , wendon j , williams r , et al . evidence of increased guanylate cyclase activation by acetylcysteine in fulminant hepatic failure [ j ] . hepatology , 1996 , 23 : 1067
徐鑫荣、俞雷、张家留.还原型谷胱甘肽和乙酰半胱氨酸对内毒素休克免的保护作用[ j ] .临床麻醉学杂志, 2001 , 17 ( 6 ) : 318 - However , there i s no direct evidence about the influences of vnp on the proliferation of other vascular smooth muscle cells . three receptors subtypes for natriuretic peptides have been identified , the natriuretic peptide receptor ( npr ) - a , npr - b and npr - c . the npr - a and npr - b are membrane - bound guanylate cyclase coupled to production of 3 " , 5 ' - cyclic guanosine - 7 - monophophate ( cgmp )
钠尿肽受体( natriureticpeptidereceptors , nprs )有a 、 b 、 c三个亚型，其中a 、 b ( npr - a 、 b )受体是鸟苷酸环化酶( gc )耦联受体，与配体结合后引起细胞内cgmp水平升高，而c受体不与gc耦联，主要通过结合和内化( internalize )钠尿肽而发挥清除受体的功能。 - The npr - c is a membrane - bound receptor that lacks the intracellular guanylate cyclase domains of the biologically active receptors and is therefore uncoupled with cgmp . npr - c functions as a clearance receptor by binding with and internalizing natriuretic peptides . nprs are widely and differently distributed in most tissues and can be up - or down - regulated in many pathological processes , which indicates that they have different effects on different tissue and participate in the regulation of their physiological and pathological process
正常情况下，三种受体在体内均广泛分布，但在不同组织中的分布有很大差异，而且在不同病理条件下钠尿肽受体数目还可发生上调和下调，提示钠尿肽家族及其受体对不同组织器官的作用不同，并参与它们的生理和病理过程的调节。